Framing multiple sclerosis under a polysomnographic perspective

Sleep. 2020 Mar 12;43(3):zsz232. doi: 10.1093/sleep/zsz232.


Multiple sclerosis (MS) is a mainly demyelinating, autoimmune, and disabling neurological disease. In addition to well-known clinically evident symptoms such as coordination or motor problems, increasing attention has been posed to a constellation of less evident symptoms significantly contributing to the clinical impact of MS. Among others, sleep symptoms have been only recently explored. This systematic review summarizes objective sleep findings detected by using polysomnography and their relationship with clinical variables in MS patients. While it is well known that sleep disorders are frequent in MS, objective clinical data are still scarce. Literature based on subjective reports indicate sleep disorders as highly frequent in MS patients; however, objective data are still scarce. New large case-control instrumental investigations are warranted to establish the real objective entity and impact of sleep comorbidities.

Keywords: AHI; PLM; PSG; RLS; apneas; multiple sclerosis; periodic leg movements; restless leg syndrome; sleep; sleep architecture.

Publication types

  • Systematic Review

MeSH terms

  • Humans
  • Multiple Sclerosis* / complications
  • Multiple Sclerosis* / epidemiology
  • Polysomnography
  • Restless Legs Syndrome*
  • Sleep
  • Sleep Wake Disorders* / diagnosis
  • Sleep Wake Disorders* / epidemiology