Comparison of accelerometer-derived physical activity levels between individuals with and without cancer: a UK Biobank study

Future Oncol. 2019 Nov;15(33):3763-3774. doi: 10.2217/fon-2019-0443. Epub 2019 Oct 22.


Aim: To identify the difference in physical activity (PA) levels between individuals with and without cancer, and to estimate all-cause mortality associated with this difference. Methods: Current cancer, cancer survivor and cancer-free groups were identified from the UK Biobank. We used multivariate and Cox regression to estimate PA differences and association of PA with all-cause mortality. Results: Compared with the cancer-free individuals, participants in the two cancer groups had fewer minutes in moderate-to-vigorous PA per day in adjusted analyses. The PA difference was associated with higher mortality in the current cancer group. Conclusion: Patients with a history of cancer were less active than those without cancer, and PA is associated with increased mortality. PA improvement strategies in cancer patients must be explored.

Keywords: UK Biobank; accelerometer; all-cause mortality; cancer; physical activity.

Publication types

  • Comparative Study

MeSH terms

  • Accelerometry / statistics & numerical data*
  • Adult
  • Aged
  • Cancer Survivors / statistics & numerical data*
  • Exercise*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / mortality
  • Neoplasms / physiopathology*
  • Prospective Studies
  • Surveys and Questionnaires / statistics & numerical data
  • Survival Analysis
  • Time Factors
  • United Kingdom / epidemiology