Quantification of Inflammation Following Nd:YAG Laser Capsulotomy and Assessing the Anti-inflammatory Effects of Nepafenac 0.1% and Betamethasone 0.1

Ocul Immunol Inflamm. 2021 Feb 17;29(2):411-416. doi: 10.1080/09273948.2019.1668025. Epub 2019 Oct 22.

Abstract

Purpose: To quantify the intraocular inflammation, measured using laser flare photometry (LFP), after Nd:YAG capsulotomy and compare the effects of different topical anti-inflammatory regimes.Methods: A single-center, prospective, randomized controlled study, which included 90 eyes of 90 patients with visually significant posterior capsular opacification. In all patients, Nd:YAG capsulotomy was done and was then randomized into three groups: (A) Topical betamethasone 0.1%; (B) Topical nepafenac 0.1%; and (C) Control group: did not receive any anti-inflammatory agent post capsulotomy.Results: There was a significant increase in the mean LFP values 2 h following laser capsulotomy (p < 0.001) and then declined gradually and came back to pre-laser values by 2 weeks in all three groups. The mean LFP values, central macular thickness, and best corrected visual acuity were comparable among groups. None developed central macular edema.Conclusion: Intraocular inflammation following Nd:YAG capsulotomies is minimal and transient. Routine use of prophylactic anti-inflammatory agents may be avoided.

Keywords: Cataract surgery; YAG cap; YAG capsulotomy; laser flare photometry; posterior capsular opacification.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Benzeneacetamides / administration & dosage*
  • Betamethasone / administration & dosage*
  • Capsule Opacification / surgery*
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Glucocorticoids / administration & dosage
  • Humans
  • Inflammation / diagnosis*
  • Inflammation / drug therapy
  • Inflammation / etiology
  • Laser Therapy / adverse effects*
  • Lasers, Solid-State / therapeutic use
  • Male
  • Middle Aged
  • Phacoemulsification / adverse effects*
  • Phenylacetates / administration & dosage*
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / drug therapy
  • Postoperative Complications / etiology
  • Prospective Studies
  • Tomography, Optical Coherence / methods
  • Treatment Outcome
  • Visual Acuity
  • Young Adult

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzeneacetamides
  • Glucocorticoids
  • Phenylacetates
  • nepafenac
  • Betamethasone