Chronic myeloid leukaemia: The dangers of not knowing your BCR-ABL1 transcript

Leuk Res. 2019 Dec;87:106231. doi: 10.1016/j.leukres.2019.106231. Epub 2019 Sep 28.
No abstract available

Keywords: ABL1; Atypical transcript; BCR; CML; GeneXpert.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • DNA Mutational Analysis
  • Diagnostic Errors*
  • Drug Resistance, Neoplasm / genetics*
  • False Negative Reactions
  • Fusion Proteins, bcr-abl / genetics*
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
  • Monitoring, Physiologic* / methods
  • Monitoring, Physiologic* / standards
  • Protein Kinase Inhibitors / therapeutic use
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors

Substances

  • Protein Kinase Inhibitors
  • Fusion Proteins, bcr-abl
  • Protein-Serine-Threonine Kinases