Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Sep 18;2019:2890193.
doi: 10.1155/2019/2890193. eCollection 2019.

Functional Evaluation of the Visual Pathway in Patients With Multiple Sclerosis Using a Multifunction Stimulator Monitor

Affiliations
Free PMC article

Functional Evaluation of the Visual Pathway in Patients With Multiple Sclerosis Using a Multifunction Stimulator Monitor

M Satue et al. J Ophthalmol. .
Free PMC article

Abstract

Objectives: To assess the capability of the vision monitor unit Monpack One of detecting visual function alterations in patients with multiple sclerosis (MS) and to evaluate the correlation between structural retinal parameters and functional measurements obtained with this device.

Methods: Forty-eight patients with MS and 46 healthy controls were included in a cross-sectional study. All participants underwent a complete functional evaluation of the visual pathway, which included low-contrast visual acuity (LCVA), contrast sensitivity vision (CSV), automated perimetry, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (ERG). All tests were performed using the vision monitor unit Monpack One (Metrovision, France), a multifunction stimulator device. Retinal structural measurements were obtained in all subjects using Triton swept source optical coherence tomography (Topcon, Japan).

Results: Patients with MS presented reduced low-contrast VA (p < 0.001) and reduced CSV at medium (p=0.001, p=0.013) and low (p=0.001, p=0.002) spatial frequencies. All visual field parameters were found to be altered in MS patients compared with controls (≤0.001). Patients with MS presented lower amplitude of the P100 waveform of the mfVEP in areas corresponding to central (p < 0.001), inferonasal (p=0.001), and inferotemporal (p=0.003) retina. The pattern ERG did not show significant differences. Significant correlations were observed between structural retinal measurements and functional parameters, especially between the inner macular areas and measurements corresponding to contrast sensitivity and perimetry indexes.

Conclusions: Patients with MS present visual dysfunction detectable with the vision monitor unit Monpack One. This device may be a fast and useful tool to provide a full evaluation of axonal damage in patients with multiple sclerosis.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Monpack One monitor. (b) Displayed report of the contrast sensitivity vision test in one of our controls. (c) Displayed report of multifocal visual evoked potentials in one of our controls.

Similar articles

See all similar articles

References

    1. Garcia-Martin E., Pueyo V., Pinilla I., Ara J.-R., Martin J., Fernandez J. Fourier-domain OCT in multiple sclerosis patients: reproducibility and ability to detect retinal nerve fiber layer atrophy. Investigative Opthalmology & Visual Science. 2011;52(7):4124–4131. doi: 10.1167/iovs.10-6643. - DOI - PubMed
    1. Fisher J., Jacobs D., Markowitz C., et al. Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophthalmology. 2006;113(2):324–332. doi: 10.1016/j.ophtha.2005.10.040. - DOI - PubMed
    1. Gordon-Lipkin E., Chodkowski B., Reich D. S., et al. Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology. 2007;69(16):1603–1609. doi: 10.1212/01.wnl.0000295995.46586.ae. - DOI - PubMed
    1. Fisher E., Lee J.-C., Nakamura K., Rudick R. A. Gray matter atrophy in multiple sclerosis: a longitudinal study. Annals of Neurology. 2008;64(3):255–265. doi: 10.1002/ana.21436. - DOI - PubMed
    1. Fisniku L. K., Chard D. T., Jackson J. S, et al. Gray matter atrophy is related to long-term disability in multiple sclerosis. Annals of Neurology. 2008;64:247–254. doi: 10.1002/ana.21423. - DOI - PubMed

LinkOut - more resources

Feedback