To study the salivary cortisol level, and to analyze the correlation between salivary cortisol and peri-abortion depression in the women suffering termination of pregnancy for fetal anomaly. Methods: Comparing the difference in salivary cortisol level between the women with and without depression when they underwent termination of pregnancy for fetal anomaly in a prospective cohort study. Analyzing the correlation between salivary cortisol and peri-abortion depression through logistics regression analysis. Results: The salivary cortisol awakening response was lower in women with depression than women without depression. Based on the logistics regression analysis, the salivary cortisol awakening response showed a negative correlation with pre-abortion (OR=0.063, 95% CI 0.005 to 0.754) and post-abortion (OR=0.002, 95% CI 0.000 to 0.061) depression. Conclusion: Cortisol awakening response possesses a negative correlation with peri-abortion depression, and it is a predictive factor for post-abortion depression.
目的：探索胎儿畸形引产女性引产前唾液皮质醇水平的相关参数与围引产期抑郁的关系。方法：比较胎儿畸形女性引产前后抑郁组与非抑郁组之间唾液皮质醇水平的差异，应用logistics回归分析唾液皮质醇与围引产期抑郁发生的相关关系。结果：胎儿畸形引产女性抑郁组唾液皮质醇觉醒反应低于非抑郁组，引产前唾液皮质醇觉醒反应与引产前(OR=0.063，95% CI：0.005~0.754)和引产后3个月(OR=0.002，95% CI：0.000~0.061)抑郁的发生呈负相关。结论：唾液皮质醇觉醒反应越高，围引产期抑郁发生率越低，提示胎儿畸形引产女性引产前唾液皮质醇觉醒反应对引产后抑郁的发生有预测作用。.