Temporal changes in urinary excretion of liver-type fatty acid binding protein (L-FABP) in acute kidney injury model of domestic cats: a preliminary study

J Vet Med Sci. 2019 Dec 26;81(12):1868-1872. doi: 10.1292/jvms.19-0325. Epub 2019 Oct 22.

Abstract

Liver-type fatty acid-binding protein (L-FABP) is a biomarker for the early detection of renal diseases in humans. It is secreted along with cytotoxic oxidation products from proximal tubular epithelial cells under conditions of ischemia and/or oxidative stress. This study examined urinary L-FABP excretion under renal ischemia in feline acute kidney injury (AKI) model. L-FABP excretion increased immediately after renal ischemia/reperfusion, despite the absence of obvious structural damage to the kidneys, in the two AKI model cats studied. L-FABP was detected in the renal tubular lumen immediately after renal ischemia/reperfusion in the two cats, but not in a sham surgery cat. These results suggested that high L-FABP excretion is a pathophysiological response associated with antioxidant defense in proximal tubules with renal ischemia and/or oxidative stress in a feline model.

Keywords: Liver-type fatty acid–binding protein (L-FABP); acute kidney injury; biomarker; cat model.

MeSH terms

  • Acute Kidney Injury / pathology
  • Acute Kidney Injury / veterinary*
  • Animals
  • Biomarkers / metabolism
  • Cat Diseases / pathology*
  • Cat Diseases / urine
  • Cats
  • Fatty Acid-Binding Proteins / urine*
  • Ischemia / veterinary
  • Kidney / pathology
  • Male
  • Reperfusion Injury / veterinary

Substances

  • Biomarkers
  • Fatty Acid-Binding Proteins