Polymersomes with aggregation-induced emission based on amphiphilic block copolypeptoids

Xinfeng Tao; Hui Chen; Sylvain Trépout; Jiayu Cen; Jun Ling; Min-Hui Li

doi:10.1039/c9cc07501a

Polymersomes with aggregation-induced emission based on amphiphilic block copolypeptoids

Chem Commun (Camb). 2019 Nov 7;55(90):13530-13533. doi: 10.1039/c9cc07501a.

Authors

Xinfeng Tao¹, Hui Chen², Sylvain Trépout³, Jiayu Cen⁴, Jun Ling⁴, Min-Hui Li⁵

Affiliations

¹ Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China and Chimie ParisTech, PSL Université Paris, CNRS, Institut de Recherche de Chimie Paris, UMR8247, 11 rue Pierre et Marie Curie, 75005 Paris, France. min-hui.li@chimieparistech.psl.eu.
² Chimie ParisTech, PSL Université Paris, CNRS, Institut de Recherche de Chimie Paris, UMR8247, 11 rue Pierre et Marie Curie, 75005 Paris, France. min-hui.li@chimieparistech.psl.eu.
³ Institut Curie, PSL Université Paris, INSERM U1196 and CNRS UMR9187, 91405 Orsay Cedex, France.
⁴ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
⁵ Chimie ParisTech, PSL Université Paris, CNRS, Institut de Recherche de Chimie Paris, UMR8247, 11 rue Pierre et Marie Curie, 75005 Paris, France. min-hui.li@chimieparistech.psl.eu and Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, 15 North Third Ring Road, Chaoyang District, 100029 Beijing, China.

PMID: 31647088
DOI: 10.1039/c9cc07501a

Abstract

Biocompatible polymersomes are prepared from amphiphilic block copolypeptoids with aggregation-induced emission, where the hydrophobic block P(TPE-NAG) is a tetraphenylethylene (TPE)-modified poly(N-allylglycine) and the hydrophilic block is polysarcosine. These nanoparticles are non-cytotoxic and show strong fluorescence emission in aqueous solution.