Defining the Genetics of Basosquamous Carcinoma

Eric Tarapore; Scott X Atwood

doi:10.1016/j.jid.2019.04.011

Defining the Genetics of Basosquamous Carcinoma

J Invest Dermatol. 2019 Nov;139(11):2258-2260. doi: 10.1016/j.jid.2019.04.011.

Authors

Eric Tarapore¹, Scott X Atwood²

Affiliations

¹ Department of Developmental and Cell Biology, University of California, Irvine, California, USA.
² Department of Developmental and Cell Biology, University of California, Irvine, California, USA; Department of Dermatology, University of California, Irvine, California, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, California USA. Electronic address: satwood@uci.edu.

PMID: 31648686
DOI: 10.1016/j.jid.2019.04.011

Abstract

Basosquamous carcinoma (BSC) is a rare form of skin cancer with both basaloid and squamous morphology. Chiang et al. (2019) genetically define BSCs and demonstrate that BSCs likely originate as basal cell carcinomas that partially squamatize through accumulation of ARID1A mutations and RAS/MAPK pathway activation.

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MeSH terms

Adaptation, Physiological
Carcinoma, Basal Cell*
Carcinoma, Basosquamous*
Humans
Mutation
Skin Neoplasms*