Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Aug 28;15:38-48.
doi: 10.1016/j.omto.2019.08.005. eCollection 2019 Dec 20.

Immunotherapeutic Challenges for Pediatric Cancers

Affiliations
Free PMC article
Review

Immunotherapeutic Challenges for Pediatric Cancers

Brian Hutzen et al. Mol Ther Oncolytics. .
Free PMC article

Abstract

Solid tumors contain a mixture of malignant cells and non-malignant infiltrating cells that often create a chronic inflammatory and immunosuppressive microenvironment that restricts immunotherapeutic approaches. Although childhood and adult cancers share some similarities related to microenvironmental changes, pediatric cancers are unique, and adult cancer practices may not be wholly applicable to our pediatric patients. This review highlights the differences in tumorigenesis, viral infection, and immunologic response between children and adults that need to be considered when trying to apply experiences from experimental therapies in adult cancer patients to pediatric cancers.

Keywords: CAR T cells; brain tumor; dendritic cell vaccine; immunosuppression; immunotherapy; metabolic antagonism; natural killer cells; neo-antigen; oncolytic virotherapy; sarcoma.

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Yang L., Lin P.C. Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression. Semin. Cancer Biol. 2017;47:185–195. - PMC - PubMed
    1. Radons J. The role of inflammation in sarcoma. Adv. Exp. Med. Biol. 2014;816:259–313. - PubMed
    1. Kohanbash G., Carrera D.A., Shrivastav S., Ahn B.J., Jahan N., Mazor T., Chheda Z.S., Downey K.M., Watchmaker P.B., Beppler C. Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas. J. Clin. Invest. 2017;127:1425–1437. - PMC - PubMed
    1. Guo X., Xue H., Shao Q., Wang J., Guo X., Chen X., Zhang J., Xu S., Li T., Zhang P. Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR. Oncotarget. 2016;7:80521–80542. - PMC - PubMed
    1. Campbell B.B., Light N., Fabrizio D., Zatzman M., Fuligni F., de Borja R., Davidson S., Edwards M., Elvin J.A., Hodel K.P. Comprehensive Analysis of Hypermutation in Human Cancer. Cell. 2017;171:1042–1056.e10. - PMC - PubMed

LinkOut - more resources

Feedback