Swept-source Optical Coherence Tomography Angiography Findings in Uveitic Cystoid Macular Edema

Ocul Immunol Inflamm. 2019;27(8):1211-1223. doi: 10.1080/09273948.2019.1672195. Epub 2019 Oct 25.

Abstract

Purpose: To describe swept-source optical coherence tomography angiography (OCTA) findings in uveitic cystoid macular edema (CME).Methods: Prospective study of 36 eyes.Results: Cystoid black spaces were shown in the deep capillary plexus (DCP) in 36 eyes (100%) and in the superficial capillary plexus (SCP) in 6 eyes (16.7%). Grayish areas of capillary non perfusion/hypoperfusion were seen in 69.4% of eyes in the DCP (vs 25% in the SCP, p < .001). The foveal avascular zone was larger than in the control healthy eyes in the DCP (p < .001). Capillary density was lower than in the control group in the SCP (p = .001) and the DCP (p < .001). Of 11 eyes with resolved CME on OCT, 4 eyes showed complete recovery of both plexuses on OCTA. There was a persistence of areas of capillary rarefaction in 4 eyes, and of hypoperfusion/nonperfusion in 3 eyes.Conclusion: OCTA visualizes perifoveal microvascular changes in uveitic CME.

Keywords: Fluorescein angiography; macular edema; optical coherence tomography; optical coherence tomography angiography; swept-source technology; uveitis.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Capillaries / pathology
  • Child
  • Female
  • Fluorescein Angiography / methods*
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Macula Lutea / pathology*
  • Macular Edema / diagnosis*
  • Macular Edema / etiology
  • Male
  • Middle Aged
  • Prospective Studies
  • Retinal Vessels / pathology*
  • Tomography, Optical Coherence / methods*
  • Uveitis / complications*
  • Uveitis / diagnosis
  • Visual Acuity*
  • Young Adult