The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity

Int J Mol Sci. 2019 Oct 22;20(20):5238. doi: 10.3390/ijms20205238.


Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI.

Keywords: acute kidney injury; cisplatin nephrotoxicity; kidney injury molecule-1.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Acute Kidney Injury / diagnosis*
  • Acute Kidney Injury / metabolism
  • Animals
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / toxicity*
  • Apoptosis
  • Biomarkers / metabolism
  • Cisplatin / adverse effects
  • Cisplatin / toxicity*
  • Hepatitis A Virus Cellular Receptor 1 / genetics
  • Hepatitis A Virus Cellular Receptor 1 / metabolism*
  • Humans
  • Kidney / drug effects
  • Kidney / metabolism*


  • Antineoplastic Agents
  • Biomarkers
  • HAVCR1 protein, human
  • Hepatitis A Virus Cellular Receptor 1
  • Cisplatin