Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis

Reprod Biomed Online. 2019 Dec;39(6):905-915. doi: 10.1016/j.rbmo.2019.07.037. Epub 2019 Aug 13.


Second-generation preimplantation genetic testing for aneuploidy (PGT-A 2.0) in patients with an unfavourable reproductive and IVF prognosis is becoming common practice, with the aim of improving reproductive outcomes. However, there is still no clear evidence on the possible advantages and drawbacks with regard to this procedure. In this discussion paper, based on a SWOT (strengths, weaknesses, opportunities, threats) analysis, the different aspects of this strategy are evaluated. Current evidence suggests that PGT-A 2.0 should not at present have an indiscriminate application, but it might be indicated in cases in which the risk of aneuploidy is increased.

Keywords: Assisted reproduction; Blastocyst biopsy; Implantation; Infertility; Live birth; Preimplantation genetic testing.

Publication types

  • Review

MeSH terms

  • Abortion, Spontaneous
  • Aneuploidy*
  • Female
  • Genetic Testing / methods*
  • Humans
  • Pregnancy
  • Pregnancy Rate
  • Preimplantation Diagnosis / adverse effects
  • Preimplantation Diagnosis / methods*