Therapeutic studies on vulvar vestibulitis

J Reprod Med. 1988 Jun;33(6):514-8.


Established drugs that could logically be hoped to have a beneficial effect on vulvar vestibulitis were evaluated empirically in small, uncontrolled, pilot studies. A small number of spontaneous remissions occurred in the groups using oral isotretinoin or progesterone cream. Apparent therapeutic responses were observed in women using oral dapsone, oral acyclovir or topical capsaicin. A further investigation of the last two drugs is warranted.

MeSH terms

  • Acyclovir / therapeutic use
  • Capsaicin / therapeutic use
  • Dapsone / therapeutic use
  • Drug Evaluation
  • Female
  • Humans
  • Isotretinoin
  • Progesterone / therapeutic use
  • Tretinoin / therapeutic use
  • Vulvitis / drug therapy*


  • Progesterone
  • Tretinoin
  • Dapsone
  • Isotretinoin
  • Capsaicin
  • Acyclovir