A novel marker relationship between carotid intima media thickness and disease activity score-28 in patients with rheumatoid arthritis: Human endothelial cell-specific molecule-1

Turk J Med Sci. 2019 Dec 16;49(6):1599-1605. doi: 10.3906/sag-1806-60.


Background/aim: Human endothelial cell-specific molecule-1 (endocan) is a marker of vascular endothelial dysfunction that may be used in the evaluation of inflammatory-associated atherosclerotic lesions. Endocan may be a marker for the evaluation of atherosclerosis and disease activity in rheumatoid arthritis (RA) patients.

Materials and methods: We included 39 RA patients assessed according to the American College of Rheumatology/European League Against Rheumatology 2010 diagnostic criteria and recruited 30 age- and sex-matching healthy subjects for the control group.

Results: Endocan values were 14.11 ± 3.27 for the RA patients and 12.10 ± 2.92 for the controls. The endocan values of the patients were significantly higher than those of the control group (P = 0.009). In the correlation analysis, endocan showed a significantly positive correlation with disease activity score-28 (r = 0.386, P = 0.029) and carotid intima–media thickness (cIMT) (r = 0.419, P = 0.008). Linear regression analysis revealed that there was an independent relationship between endocan and cIMT (P = 0.029).

Conclusion: Endocan can be a marker for early atherosclerosis and disease activity in RA patients.

Keywords: Human endothelial cell-specific molecule-1; rheumatoid arthritis; atherosclerosis; carotid intima–media thickness; marker.

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / blood
  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / pathology
  • Atherosclerosis / blood
  • Atherosclerosis / diagnosis
  • Atherosclerosis / etiology*
  • Atherosclerosis / pathology
  • Biomarkers / blood
  • Carotid Intima-Media Thickness*
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Proteins / blood*
  • Proteoglycans / blood*
  • Severity of Illness Index


  • Biomarkers
  • ESM1 protein, human
  • Neoplasm Proteins
  • Proteoglycans