Does mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?

Turk J Med Sci. 2019 Dec 16;49(6):1774-1778. doi: 10.3906/sag-1809-117.

Abstract

Background/aim: Fracture healing is a complex physiological process that involves a well-orchestrated series of biological events. The mammalian target of rapamycin (mTOR) and sestrin 1 (SESN 1) play a central role in cell metabolism, proliferation, and survival. The aim of our study is to present serum mTOR and SESN 1 levels by comparing patients with or without bone fractures. It is also a guide for further research on the roles of these proteins in fracture healing.

Materials and methods: A total of 34 patients (10 females, 24 males) with bone fractures and 32 controls (10 females, 22 males) participated in this study. After collecting serum venous blood samples, the quantitative sandwich ELISA technique was used for the determination of serum mTOR and SESN 1 levels.

Results: The mean serum mTOR level was significantly higher in the fracture group compared to the control group (P = 0.001). However, SESN 1 levels did not significantly differ between groups (P = 0.913).

Conclusion: We found that serum mTOR levels increased on the first day after fracture compared to the control group. However, we obtained no significant difference between groups in terms of SESN 1 levels. This study may guide further clinical studies investigating the potential role of mTOR signaling in the bone healing process.

Keywords: 'Bone'; 'Fracture'; 'Sestrin'; 'mTOR'.

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Female
  • Fracture Healing* / physiology
  • Fractures, Bone / blood
  • Heat-Shock Proteins / blood*
  • Heat-Shock Proteins / physiology
  • Humans
  • Male
  • Middle Aged
  • TOR Serine-Threonine Kinases / blood*
  • TOR Serine-Threonine Kinases / physiology
  • Young Adult

Substances

  • Heat-Shock Proteins
  • SESN1 protein, human
  • MTOR protein, human
  • TOR Serine-Threonine Kinases