Effect of isotretinoin on eccrine gland function

Br J Dermatol. 1988 Jul;119(1):79-82. doi: 10.1111/j.1365-2133.1988.tb07105.x.

Abstract

Sweat secretion rate, stimulated by iontophoresis of pilocarpine, was measured before and during treatment with isotretinoin in 20 patients. Sweat secretion was increased during treatment in 15 patients (75%), but the mean increase of 15% was not statistically significant (P = 0.085, paired t-test; 95% confidence limits-0.2% to +30%) and no patients had a clinically apparent alteration of sweating. We conclude that there is no important change in stimulated sweating associated with isotretinoin therapy.

MeSH terms

  • Adolescent
  • Adult
  • Eccrine Glands / drug effects*
  • Female
  • Humans
  • Isotretinoin
  • Male
  • Sweat Glands / drug effects*
  • Sweating / drug effects
  • Tretinoin / pharmacology*
  • Tretinoin / therapeutic use

Substances

  • Tretinoin
  • Isotretinoin