Room-Temperature-Formed PEDOT:PSS Hydrogels Enable Injectable, Soft, and Healable Organic Bioelectronics

Shiming Zhang; Yihang Chen; Hao Liu; Zitong Wang; Haonan Ling; Changsheng Wang; Jiahua Ni; Betül Çelebi-Saltik; Xiaochen Wang; Xiang Meng; Han-Jun Kim; Avijit Baidya; Samad Ahadian; Nureddin Ashammakhi; Mehmet R Dokmeci; Jadranka Travas-Sejdic; Ali Khademhosseini

doi:10.1002/adma.201904752

Room-Temperature-Formed PEDOT:PSS Hydrogels Enable Injectable, Soft, and Healable Organic Bioelectronics

Adv Mater. 2020 Jan;32(1):e1904752. doi: 10.1002/adma.201904752. Epub 2019 Oct 28.

Authors

Shiming Zhang^{1

2

3

4}, Yihang Chen^{2

3

5}, Hao Liu^{1

2

3

6

7}, Zitong Wang^{1

2

3}, Haonan Ling^{2

3

8}, Changsheng Wang⁹, Jiahua Ni^{1

2

3}, Betül Çelebi-Saltik^{1

2

3}, Xiaochen Wang^{1

2

3}, Xiang Meng¹⁰, Han-Jun Kim^{1

2

3}, Avijit Baidya^{1

2

3}, Samad Ahadian^{1

2

3}, Nureddin Ashammakhi^{2

3

11}, Mehmet R Dokmeci^{2

3

11}, Jadranka Travas-Sejdic^{12

13}, Ali Khademhosseini^{1

2

3

11

14}

Affiliations

¹ Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
² Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095, USA.
³ California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
⁴ Department of Chemistry, University of Montreal, Montreal, QC, H3T 2B1, Canada.
⁵ Department of Materials Science and Engineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
⁶ The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
⁷ Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
⁸ Department of Mechanical and Aerospace Engineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
⁹ Department of Stem Cell Sciences, Graduate School of Health Sciences, Hacettepe University, Sihhiye, 06100, Ankara, Turkey.
¹⁰ Department of Engineering Physics, Polytechnique Montreal, Montreal, QC, H3C 3A7, Canada.
¹¹ Department of Radiology, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
¹² Polymer Electronic Research Centre, School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, 1023, New Zealand.
¹³ MacDiarmid Institute for Advanced Materials and Nanotechnology, Kelburn Parade, Wellington, 6140, New Zealand.
¹⁴ Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

Abstract

There is an increasing need to develop conducting hydrogels for bioelectronic applications. In particular, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hydrogels have become a research hotspot due to their excellent biocompatibility and stability. However, injectable PEDOT:PSS hydrogels have been rarely reported. Such syringe-injectable hydrogels are highly desirable for minimally invasive biomedical therapeutics. Here, an approach is demonstrated to develop injectable PEDOT:PSS hydrogels by taking advantage of the room-temperature gelation property of PEDOT:PSS. These PEDOT:PSS hydrogels form spontaneously after syringe injection of the PEDOT:PSS suspension into the desired location, without the need of any additional treatments. A facile strategy is also presented for large-scale production of injectable PEDOT:PSS hydrogel fibers at room temperature. Finally, it is demonstrated that these room-temperature-formed PEDOT:PSS hydrogels (RT-PEDOT:PSS hydrogel) and hydrogel fibers can be used for the development of soft and self-healable hydrogel bioelectronic devices.

Keywords: PEDOT:PSS hydrogel; healable; injectable; minimally invasive.

MeSH terms

Animals
Biocompatible Materials / chemistry
Biocompatible Materials / pharmacology
Cell Line
Cell Proliferation / drug effects
Electrodes
Hydrogels / chemistry*
Mice
Muscle Cells / cytology
Muscle Cells / metabolism
Polystyrenes / chemistry*
Temperature
Thiophenes / chemistry*
Transistors, Electronic

Substances

Biocompatible Materials
Hydrogels
Polystyrenes
Thiophenes
poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)

Abstract

MeSH terms

Substances

Grants and funding