DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency

Cancer Genomics Proteomics. 2019 Nov-Dec;16(6):593-601. doi: 10.21873/cgp.20162.


Background/aim: Several links between DNA replication, pluripotency and development have been recently identified. The involvement of miRNA in the regulation of cell cycle events and pluripotency factors has also gained attention.

Materials and methods: In the present study, we used the g:Profiler platform to analyze transcription factor binding sites, miRNA networks and protein-protein interactions to identify novel links among the aforementioned processes.

Results and conclusion: A complex circuitry between retinoic acid signaling, SWI/SNF components, pluripotency factors including Oct4, Sox2 and Nanog and cell cycle regulators was identified. It is suggested that the DNA replication inhibitor geminin plays a central role in this circuitry.

Keywords: DNA replication; GABA; H2AX; Oct4; geminin; mir-452; pluripotency; retinoic acid.

MeSH terms

  • Cell Cycle Proteins / metabolism
  • Databases, Genetic*
  • Geminin / metabolism*
  • Humans
  • MicroRNAs / metabolism
  • Pluripotent Stem Cells / metabolism*
  • Signal Transduction / drug effects*
  • Tretinoin / pharmacology*


  • Cell Cycle Proteins
  • GMNN protein, human
  • Geminin
  • MicroRNAs
  • Tretinoin