Human infection with a novel reassortant Eurasian-avian lineage swine H1N1 virus in northern China

Emerg Microbes Infect. 2019;8(1):1535-1545. doi: 10.1080/22221751.2019.1679611.

Abstract

Influenza A virus infections occur in different species, causing mild to severe respiratory symptoms that lead to a heavy disease burden. Eurasian avian-like swine influenza A(H1N1) viruses (EAS-H1N1) are predominant in pigs and occasionally infect humans. An influenza A(H1N1) virus was isolated from a boy who was suffering from fever and headache and designated as A/Tianjin-baodi/1606/2018(H1N1). Full-genome sequencing and phylogenetic analysis revealed that A/Tianjin-baodi/1606/2018(H1N1) is a novel reassortant EAS-H1N1 containing gene segments from EAS-H1N1 (HA and NA), classical swine H1N1(NS) and A(H1N1)pdm09(PB2, PB2, PA, NP and M) viruses. The isolation and analysis of A/Tianjin-baodi/1606/2018(H1) provide further evidence that EAS-H1N1 poses a threat to human health and greater attention should be paid to surveillance of influenza virus infection in pigs and humans.

Keywords: EAS-H1N1; Influenza A virus; Phylogenetic analysis; molecular characteristics; triple-reassortant.

MeSH terms

  • Animals
  • Child
  • China
  • Humans
  • Influenza A Virus, H1N1 Subtype / classification
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / isolation & purification*
  • Influenza in Birds / virology
  • Influenza, Human / virology*
  • Male
  • Orthomyxoviridae Infections / veterinary*
  • Orthomyxoviridae Infections / virology
  • Phylogeny
  • Poultry
  • Poultry Diseases / virology
  • Reassortant Viruses / classification
  • Reassortant Viruses / genetics
  • Reassortant Viruses / isolation & purification*
  • Swine
  • Swine Diseases / virology*

Grants and funding

This research was funded by the Tianjin Science and Technology Commission [grant number 15JCYBJC24700], a National Science and Technology Major Project [grant number 2017ZX10103007-002], and the APC was funded by the Tianjin Municipal Health and Health Committee.