A Single Dose of The Mango Leaf Extract Zynamite ® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women

Nutrients. 2019 Oct 28;11(11):2592. doi: 10.3390/nu11112592.


The mango leaf extract rich in mangiferin Zynamite® improves exercise performance when combined with luteolin or quercetin ingested at least 48 h prior to exercise. To determine whether a single dose of Zynamite® administered 1 h before exercise increases repeated-sprint performance, 20 men and 20 women who were physically active were randomly assigned to three treatments following a double-blind cross-over counterbalanced design. Treatment A, 140 mg of Zynamite®, 140 mg of quercetin, 147.7 mg of maltodextrin, and 420 mg of sunflower lecithin; Treatment B, 140 mg of Zynamite®, 140 mg of quercetin, and 2126 mg of maltodextrin and Treatment C, 2548 mg of maltodextrin (placebo). Subjects performed three Wingate tests interspaced by 4 min and a final 15 s sprint after ischemia. Treatments A and B improved peak power output during the first three Wingates by 2.8% and 3.8%, respectively (treatment x sprint interaction, p = 0.01). Vastus Lateralis oxygenation (NIRS) was reduced, indicating higher O2 extraction (treatment × sprint interaction, p = 0.01). Improved O2 extraction was observed in the sprints after ischemia (p = 0.008; placebo vs. mean of treatments A and B). Blood lactate concentration was 5.9% lower after the ingestion of Zynamite® with quercetin in men (treatment by sex interaction, p = 0.049). There was a higher Vastus Lateralis O2 extraction during 60 s ischemia with polyphenols (treatment effect, p = 0.03), due to the greater muscle VO2 in men (p = 0.001). In conclusion, a single dose of Zynamite® combined with quercetin one hour before exercise improves repeated-sprint performance and muscle O2 extraction and mitochondrial O2. consumption during ischemia. No advantage was obtained from the addition of phospholipids.

Keywords: RONS; ergogenic aids; high-intensity exercise; ischemia; metabolism; oxidative stress; oxygen extraction; polyphenols; reperfusion; sports nutrition.

MeSH terms

  • Adult
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Mangifera / chemistry*
  • Muscle, Skeletal / metabolism
  • Oxygen Consumption
  • Pain
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry*
  • Quercetin / administration & dosage
  • Quercetin / chemistry
  • Quercetin / pharmacology*
  • Running
  • Young Adult


  • Plant Extracts
  • Quercetin