Filling in the Gaps of Scleroderma Ulcer Care: A Review

Adv Skin Wound Care. 2019 Dec;32(12):553-557. doi: 10.1097/01.ASW.0000582636.98643.3b.


Digital ulcers are a serious complication in 50% of patients with scleroderma. These ulcers have the potential to resist conventional therapies. There have been several reviews of scleroderma care over the last 5 years, but there are new developments in this field that advance clinician knowledge. This review provides an overview of previous digital ulcer management and a concise summary of new peer-reviewed literature on the topic since 2015 to provide guidance to practitioners and researchers seeking well-supported and novel/off-label therapies to consider.

Publication types

  • Review

MeSH terms

  • Female
  • Fingers / pathology*
  • Humans
  • Iloprost / therapeutic use*
  • Male
  • Prognosis
  • Risk Assessment
  • Scleroderma, Localized / complications
  • Scleroderma, Localized / diagnosis*
  • Skin Ulcer / drug therapy*
  • Skin Ulcer / etiology
  • Treatment Outcome
  • Vasodilator Agents / therapeutic use*
  • Wound Healing / physiology


  • Vasodilator Agents
  • Iloprost