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, 74, e1337
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Prediabetes and Type 2 Diabetes Are Independent Risk Factors for Computed Tomography-Estimated Nonalcoholic Fatty Pancreas Disease

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Prediabetes and Type 2 Diabetes Are Independent Risk Factors for Computed Tomography-Estimated Nonalcoholic Fatty Pancreas Disease

Süleyman Ahbab et al. Clinics (Sao Paulo).

Abstract

Objectives: Nonalcoholic fatty pancreas disease (NAFPD) is characterized by excessive fat deposition in the pancreas in the absence of alcohol consumption. In this study, we aimed to detect a possible relationship between adipose tissue accumulation, prediabetes and diabetes.

Methods: This cross-sectional and retrospective study included 110 patients. Three groups were classified as controls, patients with prediabetes and patients with type 2 diabetes. The abdominal computed tomography (CT) attenuation measurement results of the pancreas were evaluated independently by two experienced radiologists. CT measurements and biochemical parameters were compared between study groups. The relationship between continuous variables was assessed by using one-way ANOVA. To determine the changes in the dependent variable for the effects on study groups, the independent variable was adjusted using ANCOVA. A p-value less than 0.05 was considered statistically significant.

Results: The presence of prediabetes and type 2 diabetes was correlated with a decrease in the mean Hounsfield Unit (HU) value of the pancreas (p=0.002). Age was determined to be an independent risk factor and was correlated with NAFPD (p=0.0001). When compared to the controls (p=0.041), 71% of patients with prediabetes and 67% of patients with type 2 diabetes were observed to have an increased incidence of NAFPD. Decreased serum amylase was found to be correlated with the mean HU value of the pancreas (p=0.043).

Conclusion: NAFPD was independently correlated with both prediabetes and type 2 diabetes adjusted for age (p=0.0001) in this study. Additionally, age was determined to be an independent risk factor and was correlated with NAFPD.

Conflict of interest statement

No potential conflict of interest was reported.

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References

    1. Haslam DW, James WP. Obesity. Lancet. 2005;366(9492):1197–209. doi: 10.1016/S0140-6736(05)67483-1. - DOI - PubMed
    1. Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881–7. doi: 10.1038/nature05488. - DOI - PubMed
    1. Wu S, Wu F, Ding Y, Hou J, Bi J, Zhang Z. Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: A systematic review and meta-analysis. Sci Rep. 2016;6:33386. doi: 10.1038/srep33386. - DOI - PMC - PubMed
    1. Della Corte C, Mosca A, Majo F, Lucidi V, Panera N, Giglioni E, et al. Nonalcoholic fatty pancreas disease and Nonalcoholic fatty liver disease: more than ectopic fat. Clin Endocrinol. 2015;83(5):656–62. doi: 10.1111/cen.12862. - DOI - PubMed
    1. Di Ciaula A, Portincasa P. Fat, epigenome and pancreatic diseases. Interplay and common pathways from a toxic and obesogenic environment. Eur J Intern Med. 2014;25(10):865–73. doi: 10.1016/j.ejim.2014.10.012. - DOI - PubMed
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