Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals

Dermatol Ther. 2019 Nov;32(6):e13146. doi: 10.1111/dth.13146. Epub 2019 Nov 13.


To compare the effectiveness of tranexamic acid (TA) combination serum with hydroquinone, the gold standard in whitening agents for healthy populations. This was a three-arm randomized controlled trial. The subjects were divided into three groups: the first group received 3% TA combination serum (3% TA, 4% galactomyces ferment filtrate, 2% niacinamide, and 4% alpha arbutin), the second group received 2% TA combination serum, and the third group received 4% hydroquinone. One milliliter of each serum was applied on three holes: Hole A, which was located 4 cm from the left cubital fossa, Hole B, which was located 4 cm from the first hole, and Hole C, which was located 4 cm from the right cubital fossa. The skin brightness and pigmentation intensity were evaluated each week for 4 weeks using a chromameter. A total of 44 subjects were recruited for this study. All groups showed a significant improvement in skin brightness and pigmentation intensity after 4 weeks (p < .001). There were no differences between the treatment groups and hydroquinone (p > .05). TA serum (2 and 3%) combined with 4% galactomyces ferment filtrate, niacinamide, and alpha arbutin is an effective depigmenting agent.

Keywords: depigmenting agent; topical tranexamic acid.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Arbutin / administration & dosage
  • Humans
  • Hydroquinones / administration & dosage*
  • Hydroquinones / pharmacology
  • Middle Aged
  • Niacinamide / administration & dosage
  • Saccharomycetales / metabolism
  • Skin Lightening Preparations / administration & dosage*
  • Skin Lightening Preparations / pharmacology
  • Skin Pigmentation / drug effects*
  • Tranexamic Acid / administration & dosage*
  • Tranexamic Acid / pharmacology


  • Hydroquinones
  • Skin Lightening Preparations
  • Niacinamide
  • Tranexamic Acid
  • Arbutin
  • hydroquinone