PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

Cancer Imaging. 2019 Oct 29;19(1):69. doi: 10.1186/s40644-019-0253-1.


Objective: The present study aimed to evaluate the diagnostic performance and safety of PET/CT-guided percutaneous core bone biopsy and to compare the PET/CT-guided method to conventional CT-guided percutaneous core biopsies to diagnose Chinese patients with bone tumors and tumor-like lesions.

Methods: Data for 97 patients with bone tumors and tumor-like lesions diagnosed by percutaneous core bone biopsy from February 2013 to November 2018 were retrospectively analyzed. The study included 42 cases in the PET/CT group and 55 cases in the CT alone group. The diagnostic performance, cost and complications associated with the intervention were compared between the two groups. All patients were eventually confirmed to have bone tumors and tumor-like lesions according to surgical pathology findings.

Results: There were no significant differences in patient characteristics (P > 0.05). For the patients in the PET/CT group, the overall diagnostic yield of the initial biopsies and the diagnostic accuracy derived from the surgically proven cases were both 97.62%, which was significantly higher than the values in the CT group during the same period (P < 0.05). No major biopsy-related complications (e.g., serious bleeding or tumor dissemination) occurred before, during, or after the intervention. Therefore, no significant difference was observed between the two groups with regard to the complication rate (P > 0.05).

Conclusion: Compared with CT-guided percutaneous bone biopsy, PET/CT-guided percutaneous bone biopsy is an effective and safe alternative with high diagnostic performance in the evaluation of hypermetabolic bone lesions to diagnose bone tumors and tumor-like lesions.

Keywords: Bone lesions; CT-guided; Complications; Diagnostic performance; FDG PET/CT; Image-guided bone biopsy.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / pathology
  • Female
  • Humans
  • Image-Guided Biopsy / methods*
  • Image-Guided Biopsy / standards
  • Male
  • Middle Aged
  • Positron Emission Tomography Computed Tomography / methods
  • Positron Emission Tomography Computed Tomography / standards*
  • Tomography, X-Ray Computed / methods
  • Tomography, X-Ray Computed / standards*