Circadian Clocks in the Regulation of Neurotransmitter Systems

Pharmacopsychiatry. 2023 May;56(3):108-117. doi: 10.1055/a-1027-7055. Epub 2019 Oct 30.


To anticipate and adapt to daily recurring events defined by the earth's rotation such as light-dark and temperature cycles, most species have developed internal, so-called circadian clocks. These clocks are involved in the regulation of behaviors such as the sleep-wake cycle and the secretion of hormones and neurotransmitters. Disruptions of the circadian system affect cognitive functions and are associated with various diseases that are characterized by altered neurotransmitter signaling. In this review, we summarize the current knowledge about the interplay of the circadian clock and the regulation of psychiatric health and disease.

Publication types

  • Review

MeSH terms

  • Circadian Clocks* / physiology
  • Circadian Rhythm / physiology
  • Humans