Mucor infection is rarely reported in non-immunocompromised population, especially in isolated gastrointestinal tracts. IgG(4)-related diseases (IgG(4)-RD) have been recognized in recent years, but secondary causes of IgG(4) elevation should be differentiated. We reported a young man with duodenal mass and ulcer and high serum IgG(4) level. Histological biopsy of the mass revealed positive mucor mycelium and infiltration of IgG(4) positive plasma cells. Serum IgG(4) decreased to normal range after surgical resection and systemic antifungal treatment. This case suggests that isolated mucor mycosis infection can develop in the digestive tract and mimics as IgG(4)-related disease.
毛霉菌感染在非免疫抑制人群中鲜有报道，单纯消化道感染更加少见。IgG(4)相关性疾病近年被越来越多的临床医师所认识，但在诊断时需谨慎地排除继发性IgG(4)升高的疾病。本例青年男性，以十二指肠肿物伴溃疡为主要表现，血清IgG(4)显著升高，十二指肠肿物病理可见毛霉菌菌丝和IgG(4)阳性浆细胞浸润。经手术切除病灶和全身抗真菌治疗后，血清IgG(4)显著下降。希望通过本病例的分析，增加临床医生对消化道毛霉菌感染的了解，并拓宽对IgG(4)相关性疾病鉴别诊断的思路。.
Keywords: Duodenal ulcer; IgG(4)-related diseases; Mucor infection.