Molecular characterization and gene expression data of liver expressed antimicrobial Peptide-2 (LEAP-2) isolated from rock bream (Oplegnathus fasciatus)

Seong Don Hwang; Min Soo Joo; Jee Youn Hwang; Mun-Gyeong Kwon; Ji-Min Jeong; Jung Soo Seo; Bo-Yeong Jee; Chan-Il Park

doi:10.1016/j.dib.2019.104538

Molecular characterization and gene expression data of liver expressed antimicrobial Peptide-2 (LEAP-2) isolated from rock bream (Oplegnathus fasciatus)

Data Brief. 2019 Sep 19:26:104538. doi: 10.1016/j.dib.2019.104538. eCollection 2019 Oct.

Authors

Seong Don Hwang¹, Min Soo Joo², Jee Youn Hwang¹, Mun-Gyeong Kwon¹, Ji-Min Jeong¹, Jung Soo Seo¹, Bo-Yeong Jee¹, Chan-Il Park²

Affiliations

¹ Aquatic Animal Disease Control Center, National Institute of Fisheries Science (NIFS), 216 Gijanghaean-ro, Gijang-eup, Gijang-gun, Busan 46083, Republic of Korea.
² Institute of Marine Industry, College of Marine Science, Gyeongsang National University, 455, Tongyeong 650-160, Republic of Korea.

Abstract

Antimicrobial peptides (AMPs) are known to play a role as a first line of defence against microbial invasion. Liver Expressed Antimicrobial Peptides-2 (LEAP-2) is one of the AMPs. LEAP-2 includes four highly conserved cysteine residues and belongs to a cysteine-rich peptides group. We identified and characterized the molecular properties of LEAP-2 in rock bream. The expression levels of rock bream LEAP-2 (RbLEAP-2) in the 12 different tissues of healthy fish and the RbLEAP-2 expression pattern after infections with Edwardsiella piscicida (E. piscicida), Streptococcus iniae (S. iniae) and red seabream iridovirus (RSIV) were examined. This data provide that RbLEAP-2 plays an important role in innate immunity when rock bream is infected with a pathogen.

Keywords: Antimicrobial activity; Antimicrobial peptides; Innate immune system; Liver expressed antimicrobial Peptide-2; Rock bream.