Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention

Paul Basil; Qi Li; Grainne M McAlonan; Pak-Chung Sham

doi:10.1016/j.dib.2019.104561

Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention

Data Brief. 2019 Sep 26:26:104561. doi: 10.1016/j.dib.2019.104561. eCollection 2019 Oct.

Authors

Paul Basil^{1

2}, Qi Li¹, Grainne M McAlonan^{1

3}, Pak-Chung Sham^{1

4}

Affiliations

¹ Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region of China.
² Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
³ Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK.
⁴ State Key Laboratory of Brain and Cognitive Sciences and Centre for PanorOmicGenomic Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region of China.

Abstract

DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. This manuscript presents genome-wide DNA methylation data (GSE102942) generated from adult offspring brain prenatally exposed to Maternal Immune Activation (MIA). Methylome of the adult brain supplemented with omega-3 polyunsaturated fatty acids (PUFA) is also described. DNA methylation across gene regulatory regions were measured using MSP-I digestion and Reduced Representation Bisulfite Sequencing (RRBS) method.

Keywords: Epigenetics; MSP-I; Maternal immune activation; Methylation; Next generation sequencing (NGS); PolyI:C; Reduced representation bisulfite sequencing (RRBS).