Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery

Kimberly N Weaver; Bharati Kochar; Jonathan J Hansen; Kim L Isaacs; Animesh Jain; Shehzad Z Sheikh; Alessandro Fichera; Nicole Chaumont; Tim Sadiq; Mark Koruda; Millie D Long; Hans H Herfarth; Edward L Barnes

doi:10.1093/crocol/otz029

Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery

Crohns Colitis 360. 2019 Oct;1(3):otz029. doi: 10.1093/crocol/otz029. Epub 2019 Sep 26.

Authors

Kimberly N Weaver¹, Bharati Kochar^{1

2}, Jonathan J Hansen^{1

2

3}, Kim L Isaacs^{1

2

3}, Animesh Jain^{1

2

3}, Shehzad Z Sheikh^{1

2

3}, Alessandro Fichera^{2

4}, Nicole Chaumont^{2

4}, Tim Sadiq^{2

4}, Mark Koruda^{2

4}, Millie D Long^{1

2

3}, Hans H Herfarth^{1

2

3}, Edward L Barnes^{1

2

3}

Affiliations

¹ Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
² Multidisciplinary Center for Inflammatory Bowel Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC.
³ Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁴ Division of Gastrointestinal Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Abstract

Background: Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood.

Methods: Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP.

Results: Individuals with CADP were significantly older (40.9 vs 30.8 years, P < 0.001) and demonstrated a longer disease duration before IPAA (10.3 vs 7.0 years, P = 0.004). Age ≥55 years at the time of IPAA was significantly associated with CADP (adjusted odds ratio = 4.35, 95% confidence interval = 1.01-18.7).

Conclusions: Although older age should not represent a barrier to IPAA, further studies evaluating etiologies of this association are warranted.

Keywords: age; chronic antibiotic dependent pouchitis; ileal pouch-anal anastomosis.

Grants and funding

UL1 TR002489/TR/NCATS NIH HHS/United States