Putting an end to the Pseudomonas aeruginosa IQS controversy

Microbiologyopen. 2020 Feb;9(2):e962. doi: 10.1002/mbo3.962. Epub 2019 Oct 30.

Abstract

Despite published evidence that IQS (2-(2-hydroxylphenyl)-thiazole-4-carbaldehyde) is in fact aeruginaldehyde, a by-product of the siderophore pyochelin biosynthesis or degradation and that the ambABCDE genes are not responsible for IQS synthesis, several authors, including in top review journals, perpetuate the wrong information. I hope that this short comment will clarify the situation once and for all.

Keywords: Pseudomonas aeruginosa; IQS; aeruginaldehyde; pyochelin; quorum sensing.

Publication types

  • Letter

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Metabolic Networks and Pathways*
  • Molecular Structure
  • Phenols / chemistry
  • Phenols / metabolism*
  • Pseudomonas aeruginosa / physiology*
  • Quorum Sensing
  • Siderophores / metabolism
  • Thiazoles / chemistry
  • Thiazoles / metabolism*

Substances

  • Bacterial Proteins
  • Phenols
  • Siderophores
  • Thiazoles
  • aeruginaldehyde
  • pyochelin