Evaluation of SCUBE-1 levels as a placental dysfunction marker at gestational diabetes mellitus

Gynecol Endocrinol. 2020 May;36(5):417-420. doi: 10.1080/09513590.2019.1683537. Epub 2019 Oct 31.


Objective: To evaluate the alteration of plasma levels of signal peptide-CUB-EGF domain-containing protein (SCUBE)-1 as a marker of endothelial dysfunction and vascular injury in gestational diabetes mellitus (GDM) in comparison to healthy pregnant controls.Methods: A prospective study conducted at an antenatal outpatient clinic of a University hospital. Fifty pregnancies with GDM and thirty healthy pregnancies as controls were enrolled in the study.Results: There was no statistically significant difference between the groups in terms of age, gravidity, weight and BMI from pre-pregnancy until delivery, total weight gain, fetal weight and other hematological and biochemical parameters. SCUBE-1 levels were significantly higher in GDM patients (p = .007).Conclusions: Hyperglycemia predisposes to endothelial injury and vascular remodeling at GDM, and therefore, SCUBE-1 could be a predictor of vascular injury during pregnancy. Our study is the first to illustrate increased SCUBE-1 levels in GDM as a marker of placental endothelial dysfunction.

Keywords: SCUBE-1; endothelial dysfunction; gestational diabetes mellitus; placenta; pregnancy.

MeSH terms

  • Adult
  • Calcium-Binding Proteins / blood*
  • Case-Control Studies
  • Diabetes, Gestational / blood*
  • Diabetes, Gestational / physiopathology
  • Endothelium, Vascular / physiopathology*
  • Female
  • Humans
  • Placenta / physiopathology*
  • Pregnancy
  • Prospective Studies


  • Calcium-Binding Proteins
  • SCUBE1 protein, human