Proton Therapy

Hematol Oncol Clin North Am. 2019 Dec;33(6):989-1009. doi: 10.1016/j.hoc.2019.08.006. Epub 2019 Oct 1.


Proton therapy is a form of external beam radiotherapy that has several advantages over conventional photon (x-ray) radiotherapy. Protons are useful in 2 scenarios that apply to a large proportion of cancer patients: lack of exit dose allows for delivery of a therapeutic radiation dose to tumors in challenging anatomic locations, and reduction in integral dose (low-dose bath) to normal tissues that may reduce the risk of late toxicities and secondary cancers. The emergence of smaller, more economically viable single-room proton units has led to the expansion in use of this technology across the world.

Keywords: Bragg peak; Charged ion therapy; Charged particle therapy; Ion therapy; Particle therapy; Proton therapy; Protons; Single-room proton unit.

Publication types

  • Review

MeSH terms

  • Humans
  • Neoplasms / radiotherapy*
  • Organs at Risk / radiation effects*
  • Proton Therapy / methods*
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted / methods*