Laboratory Assays of Immune Cell Function in Immunodeficiencies

Clin Lab Med. 2019 Dec;39(4):609-623. doi: 10.1016/j.cll.2019.07.008. Epub 2019 Oct 3.

Abstract

Laboratory assays of immune cell function are essential for understanding the type and function of immune defects. These assessments should be performed in conjunction with a detailed history and physical examination, which should guide the evaluation of patients with a suspected immune deficiency. Laboratory assays of immune cell function are critical for assessing and demonstrating the functional impact of genetic mutations. Advances in diagnostic techniques continue to expand the ability of clinicians and researchers to understand the complex immune pathophysiology that underlies these disorders.

Keywords: Immune cell function; Immunodeficiency; Laboratory assay.

Publication types

  • Review

MeSH terms

  • Cytological Techniques*
  • Genetic Testing*
  • Humans
  • Immunologic Deficiency Syndromes* / diagnosis
  • Immunologic Deficiency Syndromes* / physiopathology
  • Immunologic Tests*
  • Leukocytes* / cytology
  • Leukocytes* / immunology
  • Leukocytes* / physiology