[Diabetes mellitus and risk of hip fracture. A systematic review]

Abstract

Background and objectives: It has been reported that the risk of fracture is increased in patients with diabetes mellitus (DM). The aim of this study was to investigate the possible relationship between DM and hip fracture, as well as any associated risk factors, by means of a systemic review of the literature.

Methods: PubMed and SCOPUS databases were used to search for relevant studies published from January 2001 to August 2018. Retrospective and prospective cohort studies were selected in which the estimated risk of hip fracture was demonstrated by comparing groups of diabetic patients with non-diabetics. A search was also made for risk factors independent from the association between DM and hip fracture.

Results: A total of 27 articles that fulfilled the inclusion criteria were included. A clear association was observed in diabetic patients (women and men) compared to non-diabetics patients. Among the risk factors, the most important ones were the fact that diabetes was type 1, probably associated with greater risk to a longer duration of DM, and being a female.

Conclusions: There is an increased risk of hip fracture in patients diagnosed with DM. This association is more significant in diabetes type 1 and women.

Keywords: Diabetes mellitus; Factores de riesgo; Fractura de cadera; Hip fracture; Risk factors.