Dynamic DNA nanostructures in biomedicine: Beauty, utility and limits

Ali Jahanban-Esfahlan; Khaled Seidi; Mehdi Jaymand; Thorsten L Schmidt; Hasan Majdi; Tahereh Javaheri; Rana Jahanban-Esfahlan; Peyman Zare

doi:10.1016/j.jconrel.2019.10.003

Dynamic DNA nanostructures in biomedicine: Beauty, utility and limits

J Control Release. 2019 Dec 10:315:166-185. doi: 10.1016/j.jconrel.2019.10.003. Epub 2019 Oct 24.

Authors

Ali Jahanban-Esfahlan¹, Khaled Seidi², Mehdi Jaymand³, Thorsten L Schmidt⁴, Hasan Majdi⁵, Tahereh Javaheri⁶, Rana Jahanban-Esfahlan⁷, Peyman Zare⁸

Affiliations

¹ Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
⁴ Physics Department, 103 Smith Hall, Kent State University, Kent, OH, 44240, USA.
⁵ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Ludwig Boltzmann Institute for Cancer Research, 1090 Vienna, Austria. Electronic address: zohre.javaheri@gmail.com.
⁷ Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Faculty of Medicine, Cardinal Stefan Wyszyński University in Warsaw, 01-938 Warsaw, Poland. Electronic address: jahanbanr@tbzmed.ac.ir.
⁸ Faculty of Medicine, Cardinal Stefan Wyszyński University in Warsaw, 01-938 Warsaw, Poland. Electronic address: peymanzare33@gmail.com.

PMID: 31669209
DOI: 10.1016/j.jconrel.2019.10.003

Abstract

DNA composite materials are at the forefront, especially for biomedical science, as they can increase the efficacy and safety of current therapies and drug delivery systems. The specificity and predictability of the Watson-Crick base pairing make DNA an excellent building material for the production of programmable and multifunctional objects. In addition, the principle of nucleic acid hybridization can be applied to realize mobile nanostructures, such as those reflected in DNA walkers that sort and collect cargo on DNA tracks, DNA robots performing tasks within living cells and/or DNA tweezers as ultra-sensitive biosensors. In this review, we present the diversity of dynamic DNA nanostructures functionalized with different biomolecules/functional units, imaging smart biomaterials capable of sensing, interacting, delivery and performing complex tasks within living cells/organisms.

Keywords: Cancer detection; Cancer therapy; Drug delivery; Dynamic DNA nanodevices.

Publication types

Review

MeSH terms

Animals
DNA / chemistry*
Drug Delivery Systems*
Humans
Nanostructures*
Nanotechnology / methods

Substances

DNA