Methamphetamine administration impairs behavior, memory and underlying signaling pathways in the hippocampus

Sakineh Alizadeh Golsorkhdan; Mahdi Eskandarian Boroujeni; Abbas Aliaghaei; Mohammad Amin Abdollahifar; Afshar Ramezanpour; Reza Nejatbakhsh; Iraj Jafari Anarkooli; Elahe Barfi; Mohammad Javad Fridoni

doi:10.1016/j.bbr.2019.112300

Methamphetamine administration impairs behavior, memory and underlying signaling pathways in the hippocampus

Behav Brain Res. 2020 Feb 3:379:112300. doi: 10.1016/j.bbr.2019.112300. Epub 2019 Oct 25.

Authors

Sakineh Alizadeh Golsorkhdan¹, Mahdi Eskandarian Boroujeni², Abbas Aliaghaei³, Mohammad Amin Abdollahifar⁴, Afshar Ramezanpour⁵, Reza Nejatbakhsh¹, Iraj Jafari Anarkooli¹, Elahe Barfi⁴, Mohammad Javad Fridoni⁶

Affiliations

¹ Department of Biology and Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
² Faculty of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran; Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland.
³ Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: aghaei60@gmail.com.
⁴ Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁵ Dermatologic Ward, Valiasr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
⁶ Department of Biology and Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Electronic address: fredoni_javad@yahoo.com.

PMID: 31669515
DOI: 10.1016/j.bbr.2019.112300

Abstract

Methamphetamine (METH) is a strong psychostimulant drug which can essentially affect different brain regions. Hippocampus as one of main components of limbic system plays key roles in processing of short term, long term and spatial memory. Herein, we explored the changes in behavior, synaptic transmission and hippocampal volume along with gliosis following METH treatment. Besides, using genome-wide expression profiling, we applied a pathway-based approach to detect significantly dysregulated signaling pathways. In this regard, we found that METH administration interrupts spatial memory and long term potentiation (LTP). Additionally, stereological analysis revealed a significant alteration in hippocampal volume along with increased gliosis upon METH treatment. We also identified several signaling cascades chiefly related to synaptic transmission which were considerably interrupted in the hippocampus of METH-treated rats. Taken together, our data suggests a potential link between behavioral disruptions and dysregulated signaling pathways.

Keywords: Hippocampus; Methamphetamine; Neurotransmission; RNA-seq.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Behavior, Animal / drug effects
Central Nervous System Stimulants / administration & dosage
Central Nervous System Stimulants / pharmacology*
Disease Models, Animal
Gliosis / chemically induced*
Hippocampus / drug effects*
Hippocampus / pathology
Long-Term Potentiation / drug effects*
Male
Memory Disorders / chemically induced*
Methamphetamine / administration & dosage
Methamphetamine / pharmacology*
Rats
Rats, Sprague-Dawley
Signal Transduction / drug effects*
Spatial Memory / drug effects*
Synaptic Transmission / drug effects

Substances

Central Nervous System Stimulants
Methamphetamine