Abstract
We discuss how lipoic acid (LA), a natural antioxidant, induces apoptosis and inhibits proliferation, EMT, metastasis and stemness of cancer cells. Furthermore, owing to its ability to reduce chemotherapy-induced side effects and chemoresistance, LA appears to be a promising compound for cancer treatment.
Keywords:
Apoptosis; Cancer; Chemoresistance; Lipoic acid; Metastasis; Proliferation.
Copyright © 2019. Published by Elsevier B.V.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents / pharmacology*
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Antioxidants / pharmacology*
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Apoptosis / drug effects*
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Apoptosis / genetics
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Carcinogenesis / drug effects*
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Carcinogenesis / genetics
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Proliferation / genetics
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Epithelial-Mesenchymal Transition / drug effects
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Epithelial-Mesenchymal Transition / genetics
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Gene Expression Regulation, Neoplastic / drug effects
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Humans
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Thioctic Acid / pharmacology*
Substances
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Antineoplastic Agents
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Antioxidants
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Thioctic Acid