Lipoic acid a multi-level molecular inhibitor of tumorigenesis

Biochim Biophys Acta Rev Cancer. 2020 Jan;1873(1):188317. doi: 10.1016/j.bbcan.2019.188317. Epub 2019 Nov 1.

Abstract

We discuss how lipoic acid (LA), a natural antioxidant, induces apoptosis and inhibits proliferation, EMT, metastasis and stemness of cancer cells. Furthermore, owing to its ability to reduce chemotherapy-induced side effects and chemoresistance, LA appears to be a promising compound for cancer treatment.

Keywords: Apoptosis; Cancer; Chemoresistance; Lipoic acid; Metastasis; Proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Antioxidants / pharmacology*
  • Apoptosis / drug effects*
  • Apoptosis / genetics
  • Carcinogenesis / drug effects*
  • Carcinogenesis / genetics
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Proliferation / genetics
  • Epithelial-Mesenchymal Transition / drug effects
  • Epithelial-Mesenchymal Transition / genetics
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Thioctic Acid / pharmacology*

Substances

  • Antineoplastic Agents
  • Antioxidants
  • Thioctic Acid