Associated of rs895819 with risk of stomach neoplasms

Yu Weng; Da Wang; Rongpan Bai

doi:10.1016/j.gene.2019.144173

Associated of rs895819 with risk of stomach neoplasms

Gene. 2020 Feb 5:726:144173. doi: 10.1016/j.gene.2019.144173. Epub 2019 Oct 26.

Authors

Yu Weng¹, Da Wang², Rongpan Bai³

Affiliations

¹ Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: wangda0618@zju.edu.cn.
³ Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: rpbai@zju.edu.cn.

PMID: 31669639
DOI: 10.1016/j.gene.2019.144173

Abstract

A recent study published in GENE performed a meta-analysis on the relationship between genetic variant rs895819 in microRNA-27a and risk of stomach neoplasms, and the results indicated an association of rs895819 with increased risk of stomach neoplasms in heterogenous model among Chinese. However, the meta-analysis did not include one large sample size of study that met inclusion criteria. When including all related studies, our meta-analysis showed no significant association of rs895819 with stomach neoplasms risk in each different model in all population, Chinese and Europeans. Thus, pooling all related studies did not provide evidence on the association of rs895819 with increased risk of stomach neoplasms.

Keywords: Case-control study; Gastric cancer; Genetic variant; Meta-analysis; miRNA-27a.

Publication types

Letter
Meta-Analysis

MeSH terms

Asian People / genetics
Case-Control Studies
Genetic Predisposition to Disease / genetics*
Genotype
Humans
MicroRNAs / genetics
Polymorphism, Single Nucleotide / genetics*
Risk Factors
Stomach Neoplasms / etiology*
Stomach Neoplasms / genetics*
White People / genetics

Substances

MicroRNAs