RETRACTED ARTICLE: Crocin protects cardiomyocytes against LPS-Induced inflammation

Vafa Baradaran Rahim; Mohammad Taghi Khammar; Hassan Rakhshandeh; Alireza Samzadeh-Kermani; Azar Hosseini; Vahid Reza Askari

doi:10.1016/j.pharep.2019.07.007

RETRACTED ARTICLE: Crocin protects cardiomyocytes against LPS-Induced inflammation

Pharmacol Rep. 2019 Dec;71(6):1228-1234. doi: 10.1016/j.pharep.2019.07.007. Epub 2019 Jul 30.

Authors

Vafa Baradaran Rahim¹, Mohammad Taghi Khammar², Hassan Rakhshandeh¹, Alireza Samzadeh-Kermani³, Azar Hosseini⁴, Vahid Reza Askari⁵

Affiliations

¹ Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran.
³ Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran.
⁴ Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Hoseiniaz@mums.ac.ir.
⁵ Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: askariv941@mums.ac.ir.

PMID: 31670059
DOI: 10.1016/j.pharep.2019.07.007

Abstract

The Editor-in-Chief has retracted this article. After publication, concerns were raised regarding the authenticity of the statistical data reported in Figures 2 through 4. The authors provided some source data on request from the Journal, but this was insufficient to address the concerns raised. The Editor-in-Chief therefore no longer has confidence in the results and conclusions reported in this article. Vahid Reza Askari has stated on behalf of all authors that they disagree with this retraction.

Keywords: Cardio-Toxicity; H9c2; Inflammation; Lipopolysaccharide; Sepsis.

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology
Antioxidants / pharmacology
Carotenoids / pharmacology*
Cell Line
Cell Survival / drug effects
Cytokines / metabolism
Inflammation / chemically induced*
Inflammation / drug therapy*
Inflammation / metabolism
Inflammation Mediators / metabolism
Lipopolysaccharides / pharmacology*
Myocytes, Cardiac / drug effects*
Myocytes, Cardiac / metabolism
Nitric Oxide / metabolism
Protective Agents / pharmacology*
Rats
Signal Transduction / drug effects

Substances

Anti-Inflammatory Agents
Antioxidants
Cytokines
Inflammation Mediators
Lipopolysaccharides
Protective Agents
Nitric Oxide
Carotenoids
crocin