Vive la difference: Factors and mechanisms predicting discrepancy between iFR and FFR

Morton J Kern; Arnold H Seto

doi:10.1002/ccd.28465

Vive la difference: Factors and mechanisms predicting discrepancy between iFR and FFR

Catheter Cardiovasc Interv. 2019 Sep 1;94(3):364-366. doi: 10.1002/ccd.28465.

Authors

Morton J Kern¹, Arnold H Seto¹

Affiliation

¹ Veterans Administration Long Beach Health Care System, University of California, Irvine, California.

PMID: 31670884
DOI: 10.1002/ccd.28465

Abstract

FFR/iFR is discordant in 15-20% of cases, at times causing confusion about revascularization decisions. The CONTRAST substudy identifies lesion location, lesion severity, and bradycardia as major predictors for FFR/iFR discordance, with age a minor predictor. Each of these predictors can be explained physiologically through the mechanisms related to resting and hyperemic pressure loss across different patterns of atherosclerotic stenoses. A logical approach to using both resting and hyperemic pressure ratios is proposed.

Publication types

Editorial
Comment

MeSH terms

Coronary Angiography
Coronary Stenosis*
Coronary Vessels
Fractional Flow Reserve, Myocardial*
Humans
Severity of Illness Index
Treatment Outcome