Cranberry, D-mannose and anti-inflammatory agents prevent lower urinary tract symptoms in women undergoing prolapse surgery

Climacteric. 2020 Apr;23(2):201-205. doi: 10.1080/13697137.2019.1679110. Epub 2019 Nov 1.


Objective: We assessed the effect on lower urinary tract symptoms (LUTS) of a supplement containing cranberry, D-mannose and anti-inflammatory molecules in postmenopausal women undergoing surgery for cystocele.Study design: Forty postmenopausal women were randomized 1:1 to an active group receiving the nutritional supplement twice a day for 2 weeks starting from surgery, or to a control group receiving surgery only. Primary outcomes were the effectiveness in the postoperative LUTS and urinary tract infections (UTI). LUTS were investigated by a validated questionnaire (ICIQ-FLUTS) at baseline and at week 4. Secondary outcomes were the safety and tolerability of the supplement and other perioperative outcomes.Results: No significant differences were found in perioperative outcomes and in incidence of UTI. After surgery, women treated with the supplement experienced significantly better scores on the filling domain of the questionnaire. A non-significant decrease in voiding scores was also found. No adverse events were detected.Conclusion: The use of an oral supplement containing cranberry, D-mannose and anti-inflammatory molecules decreases the perception of LUTS in postmenopausal women after anterior colporraphy. Our data suggest that perioperative use of nutritional supplements may be useful in the management of postoperative LUTS.

Keywords: Cystocele; lower urinary tract symptoms; nutritional supplements; pelvic organ prolapse.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Anti-Inflammatory Agents / administration & dosage*
  • Drug Therapy, Combination / methods
  • Female
  • Humans
  • Lower Urinary Tract Symptoms / prevention & control*
  • Mannose / administration & dosage*
  • Pelvic Organ Prolapse / surgery
  • Postoperative Complications / prevention & control*
  • Preoperative Care / methods
  • Prospective Studies
  • Vaccinium macrocarpon*


  • Anti-Inflammatory Agents
  • Mannose