Eukaryotic Transcription Turns 50

Cell. 2019 Oct 31;179(4):808-812. doi: 10.1016/j.cell.2019.09.018.

Abstract

This year we celebrate the 50th anniversary of the discovery of the three eukaryotic RNA polymerases. Ever since this seminal event in 1969, researchers have investigated the intricate mechanisms of gene transcription with great dedication. The transcription field continues to influence developmental, stem cell, and cancer biology.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA-Directed RNA Polymerases / genetics*
  • DNA-Directed RNA Polymerases / history
  • Eukaryota / genetics*
  • History, 20th Century
  • Humans
  • Transcription Factors / genetics
  • Transcription, Genetic*

Substances

  • Transcription Factors
  • DNA-Directed RNA Polymerases