Metabolic dependencies and vulnerabilities in leukemia

Genes Dev. 2019 Nov 1;33(21-22):1460-1474. doi: 10.1101/gad.326470.119.


Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic pathways, and aberrant metabolism is central not only for leukemia proliferation and survival, but also mediates oncogene addiction with significant implications for the development of targeted therapies. This review explores leukemia metabolic circuitries feeding anabolism, redox potential, and energy required for tumor propagation with an emphasis on emerging therapeutic opportunities.

Keywords: Warburg effect; glycolysis; leukemia; metabolism; mitochondria; targeted therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Proliferation
  • Humans
  • Leukemia / metabolism*
  • Leukemia / physiopathology
  • Metabolic Networks and Pathways*
  • Oxidation-Reduction