Alternatives to Transfusion

Am J Clin Pathol. 2020 Feb 8;153(3):287-293. doi: 10.1093/ajcp/aqz175.

Abstract

Objectives: We discuss two main categories of blood substitutes: perfluorocarbons and hemoglobin-based oxygen carriers.

Methods: We provide a review of the notable products developed in both categories and include their attributes as well as their setbacks.

Results: We contribute a case report tothe growing literature of the successful use of Sanguinate.

Conclusions: We find that artificial oxygen carriers are an attractive field of research because of the practical limitations and the multitude of potential complications that surround human blood transfusions.

Keywords: Hemoglobin-based oxygen carriers; Sanguinate; Transfusion medicine.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anemia / therapy*
  • Blood Substitutes*
  • Blood Transfusion*
  • Carboxyhemoglobin / therapeutic use*
  • Fluorocarbons*
  • Hemoglobins*
  • Humans
  • Male
  • Middle Aged
  • Polyethylene Glycols / therapeutic use*
  • Treatment Outcome

Substances

  • Blood Substitutes
  • Fluorocarbons
  • Hemoglobins
  • PEGylated carboxyhemoglobin bovine
  • Polyethylene Glycols
  • Carboxyhemoglobin