Plants have been an imperative source of medicine and drugs for therapy of different ailments in humans from the early history until today. Many phytochemicals present in plants act as antioxidants and are utilized as health-protecting agents. Cinnamon, a widely used spice and folk medicine obtained from Cinnamomum zeylanicum, is an effective therapy for various diseases because of its antioxidant and protective efficacy. In the present review, we investigate the beneficial effects of cinnamon on stress-induced ailments. The data regarding therapeutic effects of cinnamon on stress-induced conditions were systematically collected from PubMed, ScienceDirect, Google Scholar, and the Web of Science databases published in the English language from 2000 until July 2018 with the following terms: cinnamon, antioxidant properties, anti-inflammatory, and multifaceted plant. The articles reviewed demonstrated that free radicals play a significant role in the pathophysiology of oxidative stress-associated diseases; therefore cinnamon, with its free radical scavenging activity, represents a promising therapeutic option for ameliorating these debilitating conditions. In this context, the use of cinnamon and its derivatives might be a beneficial way to reduce oxidative stress-induced complications. However, more studies are needed at the molecular level to understand the pathophysiology of the clinical conditions observed as a result of oxidative stress.