Cell-cell interaction in the Drosophila retina: the bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development

Cell. 1988 Oct 21;55(2):321-30. doi: 10.1016/0092-8674(88)90055-4.


Genetic mosaic studies indicate that environmental cues play a critical role in photoreceptor cell (R-cell) development in the Drosophila compound eye. Recent analysis of the sevenless gene suggests that its product, a cell surface protein containing a putative intracellular domain homologous to tryosine kinases, is a receptor for a signal specifying an R7-specific pathway of cellular development. We report the identification of a second genetic locus, bride of sevenless (boss) required for the development of R7. Genetic mosaic analysis demonstrates that boss expression is required in the R8 cell for a neighboring cell to become R7. However, the development of R1-R6 and R8 is boss-independent. These data indicate a central role for R8 in directing ommatidial assembly and are consistent with boss encoding the ligand recognized by the sevenless receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Communication*
  • Cell Differentiation
  • Drosophila / genetics*
  • Drosophila / growth & development
  • Gene Expression Regulation
  • Microscopy, Electron
  • Mosaicism
  • Photoreceptor Cells / cytology*
  • Retina / cytology*