Current treatment strategies in malignant pleural mesothelioma with a treatment algorithm

Adv Respir Med. 2019;87(5):289-297. doi: 10.5603/ARM.2019.0051.


Malignant pleural mesothelioma (MPM) is arare disease with apoor prognosis. The main therapeutic options for MPM include surgery, chemotherapy, and radiation therapy (RT). Although multimodality therapy has been reported to improve survival, not every medically operable patient is able to undergo all recommended therapy. With improvements in surgical techniques and systemic therapies, as well as advancements in RT, there has been apotential new paradigm in the management of this disease. In this review, we discuss the current literature on MPM management and propose afunctional treatment algorithm.

Keywords: chemotherapy; mesothelioma; radiotherapy; surgery.

Publication types

  • Review

MeSH terms

  • Algorithms*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Humans
  • Lung Neoplasms / mortality
  • Lung Neoplasms / therapy*
  • Mesothelioma / mortality
  • Mesothelioma / therapy*
  • Mesothelioma, Malignant
  • Neoplasm Staging
  • Prognosis
  • Survival Rate
  • Thoracic Surgical Procedures