Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate

Cell Calcium. 2019 Dec:84:102103. doi: 10.1016/j.ceca.2019.102103. Epub 2019 Oct 18.

Abstract

Recently there has been a flurry of interest in the regulation of the homo-dimeric calcium-activated chloride channel ANO1 (also known as TMEM16A) by phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2). These recent studies show that upon Ca2+ binding, PI(4,5)P2 cooperates to maintain the conductive state of ANO1. PI(4,5)P2 does so by binding to sites or modules on the protein's cytosolic side. These findings add a new function to the PI(4,5)P2 repertoire and a new dimension to ANO1 gating.

Keywords: Anion channels; Calcium; Ion channel gating; Ion channel regulation; Phospholipids.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anoctamin-1 / genetics
  • Anoctamin-1 / metabolism*
  • Calcium / metabolism*
  • Calcium Signaling
  • Cytoskeleton / metabolism*
  • Cytosol / metabolism*
  • Humans
  • Ion Channel Gating
  • Phosphatidylinositol 4,5-Diphosphate / metabolism*

Substances

  • Anoctamin-1
  • Phosphatidylinositol 4,5-Diphosphate
  • Calcium