The immunoenhancing property of dietary whey protein concentrate

Clin Invest Med. 1988 Aug;11(4):271-8.


The plaque-forming cell response to sheep red blood cells was found to be enhanced in mice fed a formula diet containing 20 g lactalbumin/100 g diet in comparison to mice fed equivalent formula diets of similar nutritional efficiency containing 20 g/100 g diet of either casein, soy, wheat or corn protein, egg albumin, beef or fish protein, Spirulina maxima, or Scenedesmus protein, or Purina mouse chow. This effect was manifest after 2 weeks and persisted for at least 8 weeks of dietary treatment. Mixing lactalbumin with either casein or soy protein in a 20 g protein/100 g diet formula significantly enhanced the immune response in comparison to that of mice fed diets containing 20% soy protein or casein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic*
  • Animals
  • Antibody-Producing Cells / immunology
  • Dietary Proteins / immunology
  • Dietary Proteins / pharmacology
  • Erythrocytes / immunology
  • Lactalbumin / immunology
  • Lactalbumin / pharmacology
  • Male
  • Mice
  • Mice, Inbred C3H
  • Milk Proteins / immunology*
  • Milk Proteins / pharmacology
  • Whey Proteins


  • Adjuvants, Immunologic
  • Dietary Proteins
  • Milk Proteins
  • Whey Proteins
  • Lactalbumin